pI: 11.5631 |
Length (AA): 259 |
MW (Da): 28445 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 245 | 1vq8 (A) | 1 | 235 | 51.00 | 0 | 1 | 1.42218 | 0.8 |
6 | 257 | 5dm6 (A) | 37 | 275 | 30.00 | 0 | 1 | 1.16607 | 1.18 |
28 | 169 | 1rl2 (A) | 60 | 194 | 36.00 | 0 | 1 | 0.970663 | -0.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126641)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G36130 | 60S ribosomal protein L8-3 |
Arabidopsis thaliana | AT2G44065 | ribosomal protein L2 family protein |
Arabidopsis thaliana | ArthCp085 | 50S ribosomal protein L2 |
Arabidopsis thaliana | AT3G51190 | 60S ribosomal protein L8-2 |
Arabidopsis thaliana | AT2G18020 | 60S ribosomal protein L8-1 |
Arabidopsis thaliana | ArthCp064 | 50S ribosomal protein L2 |
Babesia bovis | BBOV_III011800 | ribosomal protein L2 family protein |
Babesia bovis | BBOV_IV007450 | ribosomal protein L2, putative |
Brugia malayi | Bm1_09075 | 60S ribosomal protein L8 |
Brugia malayi | Bm1_11070 | Ribosomal Proteins L2, RNA binding domain containing protein |
Candida albicans | CaO19.5420 | likely mitochondrial ribosomal protein similar to S. cerevisiae RML2 (YEL050C) large subunit protein L2 |
Candida albicans | CaO19.12875 | likely mitochondrial ribosomal protein similar to S. cerevisiae RML2 (YEL050C) large subunit protein L2 |
Caenorhabditis elegans | CELE_B0250.1 | Protein RPL-2 |
Caenorhabditis elegans | CELE_F56B3.8 | Protein MRPL-2 |
Cryptosporidium hominis | Chro.70243 | 60S ribosomal protein L8 |
Cryptosporidium parvum | cgd7_2110 | 60S ribosomal proteins L8/L2 |
Chlamydia trachomatis | CT_525 | 50S ribosomal protein L2 |
Dictyostelium discoideum | DidioMp24 | ribosomal protein L2 |
Dictyostelium discoideum | DDB_G0274113 | 60S ribosomal protein L8 |
Drosophila melanogaster | Dmel_CG1263 | Ribosomal protein L8 |
Drosophila melanogaster | Dmel_CG7636 | mitochondrial ribosomal protein L2 |
Escherichia coli | b3317 | 50S ribosomal subunit protein L2 |
Echinococcus granulosus | EgrG_000970050 | 5'partial|39S ribosomal protein L2 mitochondrial|39S ribosomal protein L2, mitochondrial |
Echinococcus granulosus | EgrG_000078000 | 60S ribosomal protein L8 |
Entamoeba histolytica | EHI_127200 | 60S ribosomal protein L2/L8, putative |
Entamoeba histolytica | EHI_150470 | 60S ribosomal protein L2/L8, putative |
Entamoeba histolytica | EHI_181180 | 60S ribosomal protein L2/L8, putative |
Echinococcus multilocularis | EmuJ_000078000 | 60S ribosomal protein L8 |
Echinococcus multilocularis | EmuJ_000970050 | 39S ribosomal protein L2, mitochondrial |
Giardia lamblia | GL50803_16086 | Ribosomal protein L2 |
Homo sapiens | ENSG00000112651 | mitochondrial ribosomal protein L2 |
Homo sapiens | ENSG00000161016 | ribosomal protein L8 |
Leishmania braziliensis | LbrM.34.1350 | 60S ribosomal protein L2, putative |
Leishmania braziliensis | LbrM.34.1360 | 60S ribosomal protein L2, putative |
Leishmania braziliensis | LbrM.32.4140 | 60S ribosomal protein L2, putative |
Leishmania infantum | LinJ.35.1440 | 60S ribosomal protein L2, putative |
Leishmania infantum | LinJ.35.1450 | 60S ribosomal protein L2, putative |
Leishmania infantum | LinJ.32.4050 | 60S ribosomal protein L2, putative |
Leishmania major | LmjF.35.1430 | 60S ribosomal protein L2, putative |
Leishmania major | LmjF.35.1440 | 60S ribosomal protein L2, putative |
Leishmania major | LmjF.32.3900 | 60S ribosomal protein L2, putative |
Leishmania mexicana | LmxM.34.1430 | 60S ribosomal protein L2, putative |
Leishmania mexicana | LmxM.34.1440 | 60S ribosomal protein L2, putative |
Leishmania mexicana | LmxM.31.3900 | 60S ribosomal protein L2, putative |
Loa Loa (eye worm) | LOAG_02792 | 60S ribosomal protein L8 |
Loa Loa (eye worm) | LOAG_08167 | ribosomal Proteins L2 |
Mycobacterium leprae | ML1860c | PROBABLE 50S ribosomal protein L2 RPLB |
Mus musculus | ENSMUSG00000003970 | ribosomal protein L8 |
Mus musculus | ENSMUSG00000002767 | mitochondrial ribosomal protein L2 |
Mycobacterium tuberculosis | Rv0704 | 50S ribosomal protein L2 RplB |
Mycobacterium ulcerans | MUL_0793 | 50S ribosomal protein L2 |
Neospora caninum | NCLIV_008690 | Ribosomal protein L2, related |
Neospora caninum | NCLIV_021080 | hypothetical protein |
Oryza sativa | 6450181 | ribosomal protein L2 |
Oryza sativa | 3131421 | 50S ribosomal protein L2 |
Oryza sativa | 3131424 | 50S ribosomal protein L2 |
Oryza sativa | 9269991 | Os10g0573450 |
Oryza sativa | 4352560 | Os12g0567700 |
Plasmodium berghei | PBANKA_0915700 | 50S ribosomal protein L2, putative |
Plasmodium berghei | PBANKA_1231700 | 60S ribosomal protein L2, putative |
Plasmodium falciparum | PF3D7_1132700 | 50S ribosomal protein L2, putative |
Plasmodium falciparum | PF3D7_0516900 | 60S ribosomal protein L2 |
Plasmodium knowlesi | PKNH_1016400 | 60S ribosomal protein L2, putative |
Plasmodium knowlesi | PKNH_0930900 | 50S ribosomal protein L2, putative |
Plasmodium vivax | PVX_080405 | 60S ribosomal protein L2, putative |
Plasmodium vivax | PVX_092240 | 50S ribosomal protein L2, putative |
Plasmodium yoelii | PY05952 | ribosomal protein L2 |
Plasmodium yoelii | PY04343 | 60S ribosomal protein L8 |
Saccharomyces cerevisiae | YEL050C | mitochondrial 54S ribosomal protein RML2 |
Saccharomyces cerevisiae | YFR031C-A | ribosomal 60S subunit protein L2A |
Saccharomyces cerevisiae | YIL018W | ribosomal 60S subunit protein L2B |
Schistosoma japonicum | Sjp_0117250 | IPR002171,Ribosomal protein L2,domain-containing |
Schistosoma japonicum | Sjp_0093740 | IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0131760 | IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0133610 | IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0201040 | ko:K02938 large subunit ribosomal protein L8e, putative |
Schistosoma japonicum | Sjp_0055100 | IPR002171,Ribosomal protein L2;IPR010916,TonB box, N-terminal;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0315770 | 60S ribosomal protein L8, putative |
Schistosoma japonicum | Sjp_0118590 | IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0010210 | ko:K02886 large subunit ribosomal protein L2, putative |
Schistosoma japonicum | Sjp_0033190 | IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing |
Schistosoma japonicum | Sjp_0132460 | IPR002171,Ribosomal protein L2,domain-containing |
Schistosoma mansoni | Smp_151770 | mitochondrial ribosomal protein L2 |
Schistosoma mansoni | Smp_051260 | 60S ribosomal protein L8 |
Schmidtea mediterranea | mk4.001703.06 | 39S ribosomal protein L2, mitochondrial |
Schmidtea mediterranea | mk4.000652.07 | 60S ribosomal protein L8 |
Schmidtea mediterranea | mk4.050118.01 | |
Trypanosoma brucei gambiense | Tbg972.11.18280 | 60S ribosomal protein L2, putative,60S ribosomal protein L8, putative |
Trypanosoma brucei gambiense | Tbg972.5.1540 | 60S ribosomal protein L2, putative,60S ribosomal protein L8, putative |
Trypanosoma brucei | Tb927.5.1110 | 60S ribosomal protein L8, putative |
Trypanosoma brucei | Tb427tmp.01.7960 | 60S ribosomal protein L2, putative |
Trypanosoma brucei | Tb927.11.16280 | 60S ribosomal protein L8, putative |
Trypanosoma congolense | TcIL3000.11.16190 | 60S ribosomal protein L8, putative |
Trypanosoma congolense | TcIL3000_5_960 | 60S ribosomal protein L8, putative |
Trypanosoma cruzi | TcCLB.511527.34 | 60S ribosomal protein L2, putative |
Trypanosoma cruzi | TcCLB.508299.60 | 60S ribosomal protein L8, putative |
Trypanosoma cruzi | TcCLB.511181.100 | 60S ribosomal protein L2, putative |
Toxoplasma gondii | TGME49_254400 | LSU ribosomal protein L2P, putative |
Toxoplasma gondii | TGME49_204020 | ribosomal protein RPL8 |
Treponema pallidum | TP0192 | 50S ribosomal protein L2 |
Theileria parva | TP01_1051 | 60S ribosomal protein L8, putative |
Theileria parva | TP03_0269 | 60S ribosomal protein L2, putative |
Trichomonas vaginalis | TVAG_371270 | 60S ribosomal protein L8, putative |
Trichomonas vaginalis | TVAG_104490 | 60S ribosomal protein L8, putative |
Trichomonas vaginalis | TVAG_005910 | 50S ribosomal protein L2, putative |
Trichomonas vaginalis | TVAG_484180 | 50S ribosomal protein L2, putative |
Trichomonas vaginalis | TVAG_487750 | ribosomal protein L2, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0338 | 50S ribosomal protein L2 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu716 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.7960 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.7960 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.7960 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.7960 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.5.1110 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.1110 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.1110 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.1110 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3317 | Escherichia coli | essential | goodall |
CELE_B0250.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0250.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0250.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0250.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_F56B3.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F56B3.8 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_204020 | Toxoplasma gondii | Probably essential | sidik |
TGME49_254400 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Hepatitis C virus | Hepatitis C virus serine protease, NS3/NS4A | 54 aa | 33.3% | 48 aa | Compounds | References |
Hepatitis C virus | Hepatitis C virus NS4A protein | 54 aa | 33.3% | 48 aa | Compounds | References |